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Assessment of 1, 3 : Butadiene Exposure in Polymer Production Workers Using Hprt Mutations in Lymphocytes as a Biomarker

By Ammenheuser, Marinel M.

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Book Id: WPLBN0000204484
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: Assessment of 1, 3 : Butadiene Exposure in Polymer Production Workers Using Hprt Mutations in Lymphocytes as a Biomarker  
Author: Ammenheuser, Marinel M.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Ammenheuser, M. M. (n.d.). Assessment of 1, 3 : Butadiene Exposure in Polymer Production Workers Using Hprt Mutations in Lymphocytes as a Biomarker. Retrieved from http://netlibrary.net/


Description
Government Reference Publication

Excerpt
Excerpt: Butadiene (BD), a flammable gas with a pungent odor, is used in the manufacture of styrene-butadiene rubber and other polymers. BD is a four-carbon compound with two double bonds that can be oxidized to epoxides, which can then rearrange to form reactive metabolites. In 1995 BD ranked 36th in U.S. production volume at 3.68 billion pounds (1). Butadiene is carcinogenic in rodents. Female mice developed lung tumors after chronic exposure of only 6.25 ppm. At higher dose levels the mice developed tumors at multiple sites, including the hematopoietic system, lungs, forestomach, heart, mammary glands, and ovaries (2). Rats appear to be less sensitive but developed tumors in several organs including the pancreas, testes, uterus, and the mammary, zymbal, and thyroid glands at chronic exposure levels of 1,000 ppm (3).

 

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