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Formation and Persistence of Arylamine Dna Adducts in Vivo

By Beland, Frederick A.

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Book Id: WPLBN0000217011
Format Type: PDF eBook
File Size: 0.8 MB
Reproduction Date: 2005

Title: Formation and Persistence of Arylamine Dna Adducts in Vivo  
Author: Beland, Frederick A.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Beland, F. A. (n.d.). Formation and Persistence of Arylamine Dna Adducts in Vivo. Retrieved from

Government Reference Publication

Excerpt: Aromatic amines and amides were originally associated with the induction of bladder tumors in man and have subsequently been found to be carcinogenic at a number of sites in a variety of experimental animals (1,2). The initial step in the metabolic activation of these compounds usually involves an N-oxidation (Fig. I), which can be catalyzed by cytochrome P-450, the flavincontaining monooxygenase (FMO), or peroxidases, such as prostaglandin H synthase (PHS). Primary arylamines are N-oxidized to N-hydroxy arylamines that can undergo an acid-catalyzed reaction with DNA or can be further metabolized to a reactive electrophile through acetyl coenzyme A (AcCoA)-dependent O-acetylation, ATP-dependent O-aminoacylation, or 3-phosphoadenosine 5-phosphosulfate (PAPS)-dependent Osulfonylation. The N-oxidation of secondary arylamines results in N-hydroxy metabolites that do not react directly with DNA but are further converted into electrophilic derivatives by O-sulfonylation.


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