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Plos Biology : Detection and Characterization of Cellular Immune Responses Using Peptide–mhc Microarrays, Volume 1

By Marrack, Philippa

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Book Id: WPLBN0003921939
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Detection and Characterization of Cellular Immune Responses Using Peptide–mhc Microarrays, Volume 1  
Author: Marrack, Philippa
Volume: Volume 1
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Marrack, P. (n.d.). Plos Biology : Detection and Characterization of Cellular Immune Responses Using Peptide–mhc Microarrays, Volume 1. Retrieved from http://netlibrary.net/


Description
Description : The detection and characterization of antigen-specific T cell populations is critical for understanding the development and physiology of the immune system and its responses in health and disease. We have developed and tested a method that uses arrays of peptide–MHC complexes for the rapid identification, isolation, activation, and characterization of multiple antigen-specific populations of T cells. CD4þ or CD8þ lymphocytes can be captured in accordance with their ligand specificity using an array of peptide–MHC complexes printed on a film-coated glass surface. We have characterized the specificity and sensitivity of a peptide–MHC array using labeled lymphocytes from T cell receptor transgenic mice. In addition, we were able to use the array to detect a rare population of antigen-specific T cells following vaccination of a normal mouse. This approach should be useful for epitope discovery, as well as for characterization and analysis of multiple epitope-specific T cell populations during immune responses associated with viral and bacterial infection, cancer, autoimmunity, and vaccination.

 

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