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Plos Biology : T Cell Receptor-independent Basal Signaling Via Erk and Abl Kinases Suppresses Rag Gene Expression, Volume 1

By Marrack, Philippa

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Book Id: WPLBN0003921969
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : T Cell Receptor-independent Basal Signaling Via Erk and Abl Kinases Suppresses Rag Gene Expression, Volume 1  
Author: Marrack, Philippa
Volume: Volume 1
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Marrack, P. (n.d.). Plos Biology : T Cell Receptor-independent Basal Signaling Via Erk and Abl Kinases Suppresses Rag Gene Expression, Volume 1. Retrieved from http://netlibrary.net/


Description
Description : Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligand-independent signaling by the precursors of mature antigen receptors regulates development of B and T lymphocytes. Here we describe a basal signal that controls gene expression profiles in the Jurkat T cell line and mouse thymocytes. Using DNA microarrays and Northern blots to analyze unstimulated cells, we demonstrate that expression of a cluster of genes, including RAG-1 and RAG-2, is repressed by constitutive signals requiring the adapter molecules LAT and SLP-76. This TCR-like pathway results in constitutive low-level activity of Erk and Abl kinases. Inhibition of Abl by the drug STI-571 or inhibition of signaling events upstream of Erk increases RAG-1 expression. Our data suggest that physiologic gene expression programs depend upon tonic activity of signaling pathways independent of receptor ligation.

 

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