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Plos Biology : Crag is a Gef for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells, Volume 10

By Glover, David M.

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Book Id: WPLBN0003922266
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Crag is a Gef for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells, Volume 10  
Author: Glover, David M.
Volume: Volume 10
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Glover, D. M. (n.d.). Plos Biology : Crag is a Gef for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells, Volume 10. Retrieved from http://netlibrary.net/


Description
Description : Rhodopsins (Rhs) are light sensors, and Rh1 is the major Rh in the Drosophila photoreceptor rhabdomere membrane. Upon photoactivation, a fraction of Rh1 is internalized and degraded, but it remains unclear how the rhabdomeric Rh1 pool is replenished and what molecular players are involved. Here, we show that Crag, a DENN protein, is a guanine nucleotide exchange factor for Rab11 that is required for the homeostasis of Rh1 upon light exposure. The absence of Crag causes a light-induced accumulation of cytoplasmic Rh1, and loss of Crag or Rab11 leads to a similar photoreceptor degeneration in adult flies. Furthermore, the defects associated with loss of Crag can be partially rescued with a constitutive active form of Rab11. We propose that upon light stimulation, Crag is required for trafficking of Rh from the trans-Golgi network to rhabdomere membranes via a Rab11-dependent vesicular transport.

 

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