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Plos Biology : the Vestibular System Implements a Linear–nonlinear Transformation in Order to Encode Self-motion, Volume 10

By Storey, Kate G.

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Book Id: WPLBN0003922437
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : the Vestibular System Implements a Linear–nonlinear Transformation in Order to Encode Self-motion, Volume 10  
Author: Storey, Kate G.
Volume: Volume 10
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Storey, K. G. (n.d.). Plos Biology : the Vestibular System Implements a Linear–nonlinear Transformation in Order to Encode Self-motion, Volume 10. Retrieved from http://netlibrary.net/


Description
Description : Although it is well established that the neural code representing the world changes at each stage of a sensory pathway, the transformations that mediate these changes are not well understood. Here we show that self-motion (i.e. vestibular) sensory information encoded by VIIIth nerve afferents is integrated nonlinearly by post-synaptic central vestibular neurons. This response nonlinearity was characterized by a strong (,50%) attenuation in neuronal sensitivity to low frequency stimuli when presented concurrently with high frequency stimuli. Using computational methods, we further demonstrate that a static boosting nonlinearity in the input-output relationship of central vestibular neurons accounts for this unexpected result. Specifically, when low and high frequency stimuli are presented concurrently, this boosting nonlinearity causes an intensity-dependent bias in the output firing rate, thereby attenuating neuronal sensitivities. We suggest that nonlinear integration of afferent input extends the coding range of central vestibular neurons and enables them to better extract the high frequency features of self-motion when embedded with low frequency motion during natural movements. These findings challenge the traditional notion that the vestibular system uses a linear rate code to transmit information and have important consequences for understanding how the representation of sensory information changes across sensory Pathways.

 

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