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Plos Biology : a Novel Path to Obesity, Volume 11

By Sedwick, Caitlin

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Book Id: WPLBN0003922581
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : a Novel Path to Obesity, Volume 11  
Author: Sedwick, Caitlin
Volume: Volume 11
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


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Sedwick, C. (n.d.). Plos Biology : a Novel Path to Obesity, Volume 11. Retrieved from

Description : The hormone leptin is critical for maintaining metabolic homeostasis. Secreted by adipose tissue after a meal, leptin binds to specific leptin receptors in certain brain regions, particularly the arcuate nucleus (Arc) region of the hypothalamus. Upon receptor binding, it stimulates phosphorylation of signaling proteins such as Jak and Stat3. These in turn activate the production of neurotransmitters that control neuronal circuits dedicated to inhibiting food intake and regulating energy expenditure. Tellingly, loss of leptin, or of leptin receptors, causes obesity due to impaired satiety control and disrupted energy balance. But, as Viola Nordstrom, Richard Jennemann, Hermann-Josef Grone, and colleagues demonstrate in this week’s PLOS Biology, there are other ways leptin signaling can become disrupted.


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