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Plos Biology : a Read-through Drug Put Through Its Paces, Volume 11

By Roberts Roland G.

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Book Id: WPLBN0003922584
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : a Read-through Drug Put Through Its Paces, Volume 11  
Author: Roberts Roland G.
Volume: Volume 11
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


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G, R. R. (n.d.). Plos Biology : a Read-through Drug Put Through Its Paces, Volume 11. Retrieved from

Description : An estimated 10% of all human genetic diseases are caused by nonsense mutations. These look like the stop codons that occur naturally at the ends of protein coding sequences in our genomes, but they arise instead in the middle of the protein code, with potentially devastating consequences. Instead of faithfully trundling along a gene transcript, translating it into a useful protein product, the ribosome stops dead in its tracks, leaving the protein incomplete. If only we could somehow trick the ribosome into ignoring these premature stop signs, surely enough full-length protein could be made to substantially improve the symptoms of unfortunate patients


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