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Plos Biology : an Axonal Growth Pathway Requires an Alzheimer’s Protein, Volume 11

By Robinson, Richard

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Book Id: WPLBN0003922593
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : an Axonal Growth Pathway Requires an Alzheimer’s Protein, Volume 11  
Author: Robinson, Richard
Volume: Volume 11
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


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Robinson, R. (n.d.). Plos Biology : an Axonal Growth Pathway Requires an Alzheimer’s Protein, Volume 11. Retrieved from

Description : The brain of a patient with Alzheimer’s disease is clogged with plaques—clumps of protein whose main constituent is a small polypeptide called amyloid-beta, or a-beta. A-beta is cleaved from a larger protein called amyloid precursor protein (APP). A drug to clear a-beta remains at the top of the (unfulfilled) wish list for the disease, but it remains unclear whether the clumps are the cause or consequence of the disease, and thus whether a-beta, or some other entity, is the best target for therapy. That uncertainty is magnified by uncertainty about the function of APP—despite years of research into the pathophysiology of Alzheimer’s disease, there is still no clear understanding of what APP does outside the context of the disease. In this issue of PLOS Biology, Alessia Soldano, Bassem Hassan, and colleagues show that in the developing brain, the fly homolog of APP is needed for normal axonal outgrowth, and acts through a highly conserved signaling pathway.


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