World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation, Volume 11

By Anholt, Robert, R. H.

Click here to view

Book Id: WPLBN0003922632
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation, Volume 11  
Author: Anholt, Robert, R. H.
Volume: Volume 11
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

H. Anhol, R. R. (n.d.). Plos Biology : Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation, Volume 11. Retrieved from http://netlibrary.net/


Description
Description : The odorant receptor (OR) genes constitute the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion, through an unknown mechanism that likely exploits positive and negative regulation. We devised a genetic strategy in mice to examine OR selection by determining the transcriptional activity of an exogenous promoter homologously integrated into an OR locus. Using the tetracycline-dependent transactivator responsive promoter (teto), we observed that the OR locus imposes spatial and temporal constraints on teto-driven transcription. Conditional expression experiments reveal a developmental change in the permissiveness of the locus. Further, expression of an OR transgene that suppresses endogenous ORs similarly represses the OR-integrated teto. Neurons homozygous for the teto-modified allele demonstrate predominantly monoallelic expression, despite their potential to express both copies. These data reveal multiple axes of regulation, and support a model of initiation of OR choice limited by nonpermissive chromatin and maintained by repression of nonselected alleles.

 

Click To View

Additional Books


  • Plos Biology : Base Excision by Thymine ... (by )
  • Plos Biology : Which Primates Recognize ... (by )
  • Plos Biology : Research Ethics Recommend... (by )
  • Plos Biology : Autophagy Counterbalances... (by )
  • Plos Biology : X Chromosome Sites Autono... (by )
  • Plos Biology : the Evolutionary and Deve... (by )
  • Plos Biology : Hypoinsulinemia Regulates... (by )
  • Plos Biology : Quantitative Assessment o... (by )
  • Plos Biology : the Worldwide Variation i... (by )
  • Plos Biology : Role of the Ap2 B-appenda... (by )
  • Plos Biology : a Global Perspective on T... (by )
  • Plos Biology : Causal Modelling and Brai... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.