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Plos Biology : Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit, Volume 11

By Scott, Matthew P.

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Book Id: WPLBN0003922634
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit, Volume 11  
Author: Scott, Matthew P.
Volume: Volume 11
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Scott, M. P. (n.d.). Plos Biology : Hedgehog Signaling Acts with the Temporal Cascade to Promote Neuroblast Cell Cycle Exit, Volume 11. Retrieved from http://netlibrary.net/


Description
Description : In Drosophila postembryonic neuroblasts, transition in gene expression programs of a cascade of transcription factors (also known as the temporal series) acts together with the asymmetric division machinery to generate diverse neurons with distinct identities and regulate the end of neuroblast proliferation. However, the underlying mechanism of how this ‘‘temporal series’’ acts during development remains unclear. Here, we show that Hh signaling in the postembryonic brain is temporally regulated: excess (earlier onset of) Hh signaling causes premature neuroblast cell cycle exit and underproliferation, whereas loss of Hh signaling causes delayed cell cycle exit and excess proliferation. Moreover, the Hh pathway functions downstream of Castor but upstream of Grainyhead, two components of the temporal series, to schedule neuroblast cell cycle exit. Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis.

 

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