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Plos Biology : Bmal1 and Clock, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis, Volume 2

By O’rahilly, Steve

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Book Id: WPLBN0003922868
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Bmal1 and Clock, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis, Volume 2  
Author: O’rahilly, Steve
Volume: Volume 2
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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O’Rahilly, S. (n.d.). Plos Biology : Bmal1 and Clock, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis, Volume 2. Retrieved from http://netlibrary.net/


Description
Description : Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the counterregulatory response of corticosterone and glucagon to insulin-induced hypoglycaemia is retained. Furthermore, a high-fat diet modulates carbohydrate metabolism by amplifying circadian variation in glucose tolerance and insulin sensitivity, and mutation of Clock restores the chow-fed phenotype. Bmal1 and Clock, genes that function in the core molecular clock, exert profound control over recovery from insulin-induced hypoglycaemia. Furthermore, asynchronous dietary cues may modify glucose homeostasis via their interactions with peripheral molecular clocks.

 

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