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Plos Biology : Calcium Dynamics of Cortical Astrocytic Networks in Vivo, Volume 2

By Denk, Winfred

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Book Id: WPLBN0003922874
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Calcium Dynamics of Cortical Astrocytic Networks in Vivo, Volume 2  
Author: Denk, Winfred
Volume: Volume 2
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


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Denk, W. (n.d.). Plos Biology : Calcium Dynamics of Cortical Astrocytic Networks in Vivo, Volume 2. Retrieved from

Description : Large and long-lasting cytosolic calcium surges in astrocytes have been described in cultured cells and acute slice preparations. The mechanisms that give rise to these calcium events have been extensively studied in vitro. However, their existence and functions in the intact brain are unknown. We have topically applied Fluo-4 AM on the cerebral cortex of anesthetized rats, and imaged cytosolic calcium fluctuation in astrocyte populations of superficial cortical layers in vivo, using two-photon laser scanning microscopy. Spontaneous [Ca2þ]i events in individual astrocytes were similar to those observed in vitro. Coordination of [Ca2þ]i events among astrocytes was indicated by the broad crosscorrelograms. Increased neuronal discharge was associated with increased astrocytic [Ca2þ]i activity in individual cells and a robust coordination of [Ca2þ]i signals in neighboring astrocytes. These findings indicate potential neuron–glia communication in the intact brain.


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