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Plos Biology : Immune Activation and Cd8Þ T-cell Differentiation Towards Senescence in Hiv-1 Infection, Volume 2

By Marrack, Philippa

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Book Id: WPLBN0003922955
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Immune Activation and Cd8Þ T-cell Differentiation Towards Senescence in Hiv-1 Infection, Volume 2  
Author: Marrack, Philippa
Volume: Volume 2
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
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Publisher: Plos

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Marrack, P. (n.d.). Plos Biology : Immune Activation and Cd8Þ T-cell Differentiation Towards Senescence in Hiv-1 Infection, Volume 2. Retrieved from http://netlibrary.net/


Description
Description : Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor outcome in HIV-1 pathogenesis. However, the basis of this association remains unclear. Through ex vivo analysis of virus-specific CD8þ T-cells and the use of an in vitro model of naı¨ve CD8þ T-cell priming, we show that the activation level and the differentiation state of T-cells are closely related. Acute HIV-1 infection induces massive activation of CD8þ T-cells, affecting many cell populations, not only those specific for HIV-1, which results in further differentiation of these cells. HIV disease progression correlates with increased proportions of highly differentiated CD8þ T-cells, which exhibit characteristics of replicative senescence and probably indicate a decline in Tcell competence of the infected person. The differentiation of CD8þ and CD4þ T-cells towards a state of replicative senescence is a natural process. It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system.

 

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