World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes, Volume 2

By Cardon, Lon

Click here to view

Book Id: WPLBN0003923025
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes, Volume 2  
Author: Cardon, Lon
Volume: Volume 2
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Cardon, L. (n.d.). Plos Biology : Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes, Volume 2. Retrieved from http://netlibrary.net/


Description
Description : Identifying regions of the human genome that have been targets of natural selection will provide important insights into human evolutionary history and may facilitate the identification of complex disease genes. Although the signature that natural selection imparts on DNA sequence variation is difficult to disentangle from the effects of neutral processes such as population demographic history, selective and demographic forces can be distinguished by analyzing multiple loci dispersed throughout the genome. We studied the molecular evolution of 132 genes by comprehensively resequencing them in 24 African-Americans and 23 European-Americans. We developed a rigorous computational approach for taking into account multiple hypothesis tests and demographic history and found that while many apparent selective events can instead be explained by demography, there is also strong evidence for positive or balancing selection at eight genes in the European-American population, but none in the African-American population. Our results suggest that the migration of modern humans out of Africa into new environments was accompanied by genetic adaptations to emergent selective forces. In addition, a region containing four contiguous genes on Chromosome 7 showed striking evidence of a recent selective sweep in European-Americans. More generally, our results have important implications for mapping genes underlying complex human diseases.

 

Click To View

Additional Books


  • Plos Biology : the Costs of Carnivory, V... (by )
  • Plos Biology : an Abscisic Acid-independ... (by )
  • Plos Biology : a Predominantly Neolithic... (by )
  • Plos Biology : Flower Petals Take Shape,... (by )
  • Plos Biology : a Helical Structural Nucl... (by )
  • Plos Biology : the Emergence of Complexi... (by )
  • Plos Biology : Rare Variants Create Synt... (by )
  • Plos Biology : What Do Human Parasites D... (by )
  • Plos Biology : Surviving Endoplasmic Ret... (by )
  • Plos Biology : L-dopa is an Endogenous L... (by )
  • Plos Biology : Gene Network in Fruit Fli... (by )
  • Plos Biology : Yeast Prions ; Protein Ag... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.