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Plos Biology : Emergence of Young Human Genes After a Burst of Retroposition in Primates, Volume 3

By Wolfe, Ken

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Book Id: WPLBN0003924030
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Emergence of Young Human Genes After a Burst of Retroposition in Primates, Volume 3  
Author: Wolfe, Ken
Volume: Volume 3
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Wolfe, K. (n.d.). Plos Biology : Emergence of Young Human Genes After a Burst of Retroposition in Primates, Volume 3. Retrieved from http://netlibrary.net/


Description
Description : The origin of new genes through gene duplication is fundamental to the evolution of lineage- or species-specific phenotypic traits. In this report, we estimate the number of functional retrogenes on the lineage leading to humans generated by the high rate of retroposition (retroduplication) in primates. Extensive comparative sequencing and expression studies coupled with evolutionary analyses and simulations suggest that a significant proportion of recent retrocopies represent bona fide human genes. We estimate that at least one new retrogene per million years emerged on the human lineage during the past :63 million years of primate evolution. Detailed analysis of a subset of the data shows that the majority of retrogenes are specifically expressed in testis, whereas their parental genes show broad expression patterns. Consistently, most retrogenes evolved functional roles in spermatogenesis. Proteins encoded by X chromosome derived retrogenes were strongly preserved by purifying selection following the duplication event, supporting the view that they may act as functional autosomal substitutes during X-inactivation of late spermatogenesis genes. Also, some retrogenes acquired a new or more adapted function driven by positive selection. We conclude that retroduplication significantly contributed to the formation of recent human genes and that most new retrogenes were progressively recruited during primate evolution by natural and/or sexual selection to enhance male germline function.


 

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