World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : a Distributed Chemosensory Circuit for Oxygen Preference in C. Elegans, Volume 4

By Ahringer, Julie

Click here to view

Book Id: WPLBN0003925297
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : a Distributed Chemosensory Circuit for Oxygen Preference in C. Elegans, Volume 4  
Author: Ahringer, Julie
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


APA MLA Chicago

Ahringer, J. (n.d.). Plos Biology : a Distributed Chemosensory Circuit for Oxygen Preference in C. Elegans, Volume 4. Retrieved from

Description : The nematode Caenorhabditis elegans has complex, naturally variable behavioral responses to environmental oxygen, food, and other animals. C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1 : npr-1(lf) and naturally isolated npr- 1(215F) animals avoid high oxygen and aggregate in the presence of food: npr-1(215V) animals do not. We show here that hyperoxia avoidance integrates food with npr-1 activity through neuromodulation of a distributed oxygen-sensing network. Hyperoxia avoidance is stimulated by sGC-expressing oxygen-sensing neurons, nociceptive neurons, and ADF sensory neurons. In npr-1(215V) animals, the switch from weak aerotaxis on food to strong aerotaxis in its absence requires close regulation of the neurotransmitter serotonin in the ADF neurons: high levels of ADF serotonin promote hyperoxia avoidance. In npr-1(lf) animals, food regulation is masked by increased activity of the oxygen-sensing neurons. Hyperoxia avoidance is also regulated by the neuronal TGF-b homolog DAF-7, a secreted mediator of crowding and stress responses. DAF-7 inhibits serotonin synthesis in ADF, suggesting that ADF serotonin is a convergence point for regulation of hyperoxia avoidance. Coalitions of neurons that promote and repress hyperoxia avoidance generate a subtle and flexible response to environmental oxygen.


Click To View

Additional Books

  • Plos Biology : Exploiting Thiol Modifi C... (by )
  • Plos Biology : Regulatory Hotspots in th... (by )
  • Plos Biology : a Window Into the Working... (by )
  • Plos Biology : the Vestibular System Imp... (by )
  • Plos Biology : a Yeast Model of Fus, Vol... (by )
  • Plos Biology : Distinct Olfactory Signal... (by )
  • Plos Biology : a Global Perspective on T... (by )
  • Plos Biology : Integrating Teaching and ... (by )
  • Plos Biology : a Global Census of Fissio... (by )
  • Plos Biology : the Case for Selection at... (by )
  • Plos Biology : Bip Binding to the Er-str... (by )
  • Plos Biology : Regulatory Variation at G... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.