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Plos Biology : a Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain, Volume 4

By Jan, Yuh Nung

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Book Id: WPLBN0003925308
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : a Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain, Volume 4  
Author: Jan, Yuh Nung
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
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Publication Date:
Publisher: Plos

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Jan, Y. N. (n.d.). Plos Biology : a Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain, Volume 4. Retrieved from http://netlibrary.net/


Description
Description : The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal connectivity is a fundamental goal of neurobiology. We investigated this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal activity. The Rac1 GTPase integrates a Wnt-Frizzled-Disheveled axon-stabilizing signal and a Branchless (FGF)-Breathless (FGF receptor) axonretracting signal to modulate JNK activity. JNK activity is necessary and sufficient for axon extension, whereas the antagonistic Wnt and FGF signals act to balance the extension and retraction required for the generation of the precise wiring pattern.

 

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