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Plos Biology : Disruption-induced Mucus Secretion ; Repair and Protection, Volume 4

By Zimmerberg, Joshua

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Book Id: WPLBN0003925361
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Disruption-induced Mucus Secretion ; Repair and Protection, Volume 4  
Author: Zimmerberg, Joshua
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Publication Date:
Publisher: Plos


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Zimmerberg, J. (n.d.). Plos Biology : Disruption-induced Mucus Secretion ; Repair and Protection, Volume 4. Retrieved from

Description : When a cell suffers a plasma membrane disruption, extracellular Ca2þ rapidly diffuses into its cytosol, triggering there local homotypic and exocytotic membrane fusion events. One role of this emergency exocytotic response is to promote cell survival : the internal membrane thus added to the plasma membrane acts as a reparative ‘‘patch.’’ Another, unexplored consequence of disruption-induced exocytosis is secretion. Many of the cells lining the gastrointestinal tract secrete mucus via a compound exocytotic mechanism, and these and other epithelial cell types lining the digestive tract are normally subject to plasma membrane disruption injury in vivo. Here we show that plasma membrane disruption triggers a potent mucus secretory response from stomach mucous cells wounded in vitro by shear stress or by laser irradiation. This disruption-induced secretory response is Ca2þ dependent, and coupled to cell resealing : disruption in the absence of Ca2þ does not trigger mucus release, but results instead in cell death due to failure to reseal. Ca2þ-dependent, disruption-induced mucus secretion and resealing were also demonstrable in segments of intact rat large intestine. We propose that, in addition to promoting cell survival of membrane disruptions, disruption-induced exocytosis serves also the important protective function of liberating lubricating mucus at sites of mechanical wear and tear. This mode of mechanotransduction can, we propose, explain how lubrication in the gastrointestinal tract is rapidly and precisely adjusted to widely fluctuating, diet-dependent levels of mechanical stress.


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