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Plos Biology : the Liganding of Glycolipid Transfer Protein is Controlled by Glycolipid Acyl Structure, Volume 4

By Hughson, Fred

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Book Id: WPLBN0003925500
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : the Liganding of Glycolipid Transfer Protein is Controlled by Glycolipid Acyl Structure, Volume 4  
Author: Hughson, Fred
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Hughson, F. (n.d.). Plos Biology : the Liganding of Glycolipid Transfer Protein is Controlled by Glycolipid Acyl Structure, Volume 4. Retrieved from http://netlibrary.net/


Description
Description : Glycosphingolipids (GSLs) play major roles in cellular growth and development. Mammalian glycolipid transfer proteins (GLTPs) are potential regulators of cell processes mediated by GSLs and display a unique architecture among lipid binding/transfer proteins. The GLTP fold represents a novel membrane targeting/interaction domain among peripheral proteins. Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition. Structural comparisons show a highly conserved anchoring of galactosyl- and lactosyl-amide headgroups by the GLTP recognition center. By contrast, acyl chain chemical structure and occupancy of the hydrophobic tunnel dictate partitioning between sphingosine-in and newly-observed sphingosine-out ligandbinding modes. The structural insights, combined with computed interaction propensity distributions, suggest a concerted sequence of events mediated by GLTP conformational changes during GSL transfer to and/or from membranes, as well as during GSL presentation and/or transfer to other proteins.

 

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