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Plos Biology : Threshold-dependent Bmp-mediated Repression ; a Model for a Conserved Mechanism That Patterns the Neuroectoderm, Volume 4

By Scott, Matthew P.

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Book Id: WPLBN0003925518
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Threshold-dependent Bmp-mediated Repression ; a Model for a Conserved Mechanism That Patterns the Neuroectoderm, Volume 4  
Author: Scott, Matthew P.
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Scott, M. P. (n.d.). Plos Biology : Threshold-dependent Bmp-mediated Repression ; a Model for a Conserved Mechanism That Patterns the Neuroectoderm, Volume 4. Retrieved from http://netlibrary.net/


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Description : Subdivision of the neuroectoderm into three rows of cells along the dorsal-ventral axis by neural identity genes is a highly conserved developmental process. While neural identity genes are expressed in remarkably similar patterns in vertebrates and invertebrates, previous work suggests that these patterns may be regulated by distinct upstream genetic pathways. Here we ask whether a potential conserved source of positional information provided by the BMP signaling contributes to patterning the neuroectoderm. We have addressed this question in two ways : First, we asked whether BMPs can act as bona fide morphogens to pattern the Drosophila neuroectoderm in a dose-dependent fashion, and second, we examined whether BMPs might act in a similar fashion in patterning the vertebrate neuroectoderm. In this study, we show that graded BMP signaling participates in organizing the neural axis in Drosophila by repressing expression of neural identity genes in a threshold-dependent fashion. We also provide evidence for a similar organizing activity of BMP signaling in chick neural plate explants, which may operate by the same double negative mechanism that acts earlier during neural induction. We propose that BMPs played an ancestral role in patterning the metazoan neuroectoderm by threshold-dependent repression of neural identity genes.

 

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