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Plos Biology : X Chromosomes Alternate Between Two States Prior to Random X-inactivation, Volume 4

By Hawley, R. Scott

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Book Id: WPLBN0003925529
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : X Chromosomes Alternate Between Two States Prior to Random X-inactivation, Volume 4  
Author: Hawley, R. Scott
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Hawley, R. S. (n.d.). Plos Biology : X Chromosomes Alternate Between Two States Prior to Random X-inactivation, Volume 4. Retrieved from http://netlibrary.net/


Description
Description : Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood. We show that before X-inactivation, the two X chromosomes appear to exist in distinct states that correspond to their fates as the active and inactive X chromosomes. Xist and Tsix, noncoding RNAs that control X chromosome fates upon Xinactivation, also determine the states of the X chromosomes prior to X-inactivation. In wild-type ES cells, X chromosomes switch between states: among the progeny of a single cell, a given X chromosome exhibits each state with equal frequency. We propose a model in which the concerted switching of homologous X chromosomes between mutually exclusive future active and future inactive states provides the basis for the apparently random silencing of one X chromosome in female cells.

 

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