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Plos Biology : X Chromosome Inactivation During Drosophila Spermatogenesis, Volume 5

By Noor, Mohamed A. F.

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Book Id: WPLBN0003927175
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : X Chromosome Inactivation During Drosophila Spermatogenesis, Volume 5  
Author: Noor, Mohamed A. F.
Volume: Volume 5
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


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F. Noo, M. A. (n.d.). Plos Biology : X Chromosome Inactivation During Drosophila Spermatogenesis, Volume 5. Retrieved from

Description : Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have ‘‘escaped’’ the X chromosome and moved to the autosomes. It has been proposed that inactivation of the X chromosome during spermatogenesis contributes to these patterns : genes with a beneficial function late in spermatogenesis should be selectively favored to be autosomal in order to avoid inactivation. However, conclusive evidence for X inactivation in the male germline has been lacking. To test for such inactivation, we used a transgenic construct in which expression of a lacZ reporter gene was driven by the promoter sequence of the autosomal, testisspecific ocnus gene. Autosomal insertions of this transgene showed the expected pattern of male- and testis-specific expression. X-linked insertions, in contrast, showed only very low levels of reporter gene expression. Thus, we find that X linkage inhibits the activity of a testis-specific promoter. We obtained the same result using a vector in which the transgene was flanked by chromosomal insulator sequences. These results are consistent with global inactivation of the X chromosome in the male germline and support a selective explanation for X chromosome avoidance of genes with beneficial effects late in spermatogenesis.


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