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Plos Biology : Caenorhabditis Elegans Hcf-1 Functions in Longevity Maintenance as a Daf-16 Regulator, Volume 6

By Ebata, Atsushi

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Book Id: WPLBN0003928754
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Caenorhabditis Elegans Hcf-1 Functions in Longevity Maintenance as a Daf-16 Regulator, Volume 6  
Author: Ebata, Atsushi
Volume: Volume 6
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
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Publisher: Plos

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Ebata, A. (n.d.). Plos Biology : Caenorhabditis Elegans Hcf-1 Functions in Longevity Maintenance as a Daf-16 Regulator, Volume 6. Retrieved from http://netlibrary.net/


Description
Description : The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown. We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hcf-1 inactivation caused a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stress stimuli. HCF-1 showed ubiquitous nuclear localization and physically associated with DAF-16. Furthermore, loss of hcf-1 resulted in elevated DAF-16 recruitment to the promoters of its target genes and altered expression of a subset of DAF-16-regulated genes. We propose that HCF-1 modulates C. elegans longevity and stress response by forming a complex with DAF-16 and limiting a fraction of DAF-16 from accessing its target gene promoters, and thereby regulates DAF-16-mediated transcription of selective target genes. As HCF-1 is highly conserved, our findings have important implications for aging and FOXO regulation in mammals.

 

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