World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Darwinian Evolution on a Chip, Volume 6

By Paegel, Brian M.

Click here to view

Book Id: WPLBN0003928792
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Darwinian Evolution on a Chip, Volume 6  
Author: Paegel, Brian M.
Volume: Volume 6
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Paegel, B. M. (n.d.). Plos Biology : Darwinian Evolution on a Chip, Volume 6. Retrieved from http://netlibrary.net/


Description
Description : Computer control of Darwinian evolution has been demonstrated by propagating a population of RNA enzymes in a microfluidic device. The RNA population was challenged to catalyze the ligation of an oligonucleotide substrate under conditions of progressively lower substrate concentrations. A microchip-based serial dilution circuit automated an exponential growth phase followed by a 10-fold dilution, which was repeated for 500 log-growth iterations. Evolution was observed in real time as the population adapted and achieved progressively faster growth rates over time. The final evolved enzyme contained a set of 11 mutations that conferred a 90-fold improvement in substrate utilization, coinciding with the applied selective pressure. This system reduces evolution to a microfluidic algorithm, allowing the experimenter to observe and manipulate adaptation.

 

Click To View

Additional Books


  • Plos Biology : Eps8 Regulates Hair Bundl... (by )
  • Plos Biology : Key Features of Human Epi... (by )
  • Plos Biology : Across the Curious Parall... (by )
  • Plos Biology : Assembly of the Murine Le... (by )
  • Plos Biology : Sterol-derived Hormones C... (by )
  • Plos Biology : Neural Substrate of Body ... (by )
  • Plos Biology : All for All, Volume 4 (by )
  • Plos Biology : Chromatin Structure Regul... (by )
  • Plos Biology : Differential Age-dependen... (by )
  • Plos Biology : Mutations in the Mitochon... (by )
  • Plos Biology : Cell-by-cell Dissection o... (by )
  • Plos Biology : Predictive Spatial Dynami... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.