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Plos Biology : Darwinian Evolution on a Chip, Volume 6

By Paegel, Brian M.

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Book Id: WPLBN0003928792
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Darwinian Evolution on a Chip, Volume 6  
Author: Paegel, Brian M.
Volume: Volume 6
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


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Paegel, B. M. (n.d.). Plos Biology : Darwinian Evolution on a Chip, Volume 6. Retrieved from

Description : Computer control of Darwinian evolution has been demonstrated by propagating a population of RNA enzymes in a microfluidic device. The RNA population was challenged to catalyze the ligation of an oligonucleotide substrate under conditions of progressively lower substrate concentrations. A microchip-based serial dilution circuit automated an exponential growth phase followed by a 10-fold dilution, which was repeated for 500 log-growth iterations. Evolution was observed in real time as the population adapted and achieved progressively faster growth rates over time. The final evolved enzyme contained a set of 11 mutations that conferred a 90-fold improvement in substrate utilization, coinciding with the applied selective pressure. This system reduces evolution to a microfluidic algorithm, allowing the experimenter to observe and manipulate adaptation.


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