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Plos Biology : Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells, Volume 6

By Meletis, Konstantinos

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Book Id: WPLBN0003928981
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells, Volume 6  
Author: Meletis, Konstantinos
Volume: Volume 6
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
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Publication Date:
Publisher: Plos

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Meletis, K. (n.d.). Plos Biology : Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells, Volume 6. Retrieved from http://netlibrary.net/


Description
Description : Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scarforming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.

 

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