World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Omega-3 Fatty Acids and Inflammation ; Novel Interactions Reveal a New Step in Neutrophil Recruitment, Volume 7

By Murphy, Philip M.

Click here to view

Book Id: WPLBN0003930831
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Omega-3 Fatty Acids and Inflammation ; Novel Interactions Reveal a New Step in Neutrophil Recruitment, Volume 7  
Author: Murphy, Philip M.
Volume: Volume 7
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


APA MLA Chicago

Murphy, P. M. (n.d.). Plos Biology : Omega-3 Fatty Acids and Inflammation ; Novel Interactions Reveal a New Step in Neutrophil Recruitment, Volume 7. Retrieved from

Description : Inflammation is a physiological response to tissue trauma or infection, but leukocytes, which are the effector cells of the inflammatory process, have powerful tissue remodelling capabilities. Thus, to ensure their precise localisation, passage of leukocytes from the blood into inflamed tissue is tightly regulated. Recruitment of blood borne neutrophils to the tissue stroma occurs during early inflammation. In this process, peptide agonists of the chemokine family are assumed to provide a chemotactic stimulus capable of supporting the migration of neutrophils across vascular endothelial cells, through the basement membrane of the vessel wall, and out into the tissue stroma. Here, we show that, although an initial chemokine stimulus is essential for the recruitment of flowing neutrophils by endothelial cells stimulated with the inflammatory cytokine tumour necrosis factor-a, transit of the endothelial monolayer is regulated by an additional and downstream stimulus. This signal is supplied by the metabolism of the omega-6-polyunsaturated fatty acid (n-6-PUFA), arachidonic acid, into the eicosanoid prostaglandin-D2 (PGD2) by cyclooxygenase (COX) enzymes. This new step in the neutrophil recruitment process was revealed when the dietary n-3-PUFA, eicosapentaenoic acid (EPA), was utilised as an alternative substrate for COX enzymes, leading to the generation of PGD3. This alternative series eicosanoid inhibited the migration of neutrophils across endothelial cells by antagonising the PGD2 receptor. Here, we describe a new step in the neutrophil recruitment process that relies upon a lipid-mediated signal to regulate the migration of neutrophils across endothelial cells. PGD2 signalling is subordinate to the chemokine-mediated activation of neutrophils, but without the sequential delivery of this signal, neutrophils fail to penetrate the endothelial cell monolayer. Importantly, the ability of the dietary n-3-PUFA, EPA, to inhibit this process not only revealed an unsuspected level of regulation in the migration of inflammatory leukocytes, it also contributes to our understanding of the interactions of this bioactive lipid with the inflammatory system. Moreover, it indicates the potential for novel therapeutics that target the inflammatory system with greater affinity and/or specificity than supplementing the diet with n-3-PUFAs.


Click To View

Additional Books

  • Plos Biology : Finding the Right Plugin ... (by )
  • Plos Biology : Translation Repression in... (by )
  • Plos Biology : Components of Coated Vesi... (by )
  • Plos Biology : Dynamic Encoding of Natur... (by )
  • Plos Biology : Training-induced Plastici... (by )
  • Plos Biology : a Genetic Basis for Mecha... (by )
  • Plos Biology : Loss of Mitogen-activated... (by )
  • Plos Biology : Protein Oxidation Implica... (by )
  • Plos Biology : Location Matters ; How Sp... (by )
  • Plos Biology : Imaging Poliovirus Entry ... (by )
  • Plos Biology : Please Welcome Our First ... (by )
  • Plos Biology : Cell-passage Activity is ... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.