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Plos One : Association of Chronic Kidney Disease and Peripheral Artery Disease with Inappropriate Left Ventricular Mass, Volume 7

By Scuteri, Angelo

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Book Id: WPLBN0003934120
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Association of Chronic Kidney Disease and Peripheral Artery Disease with Inappropriate Left Ventricular Mass, Volume 7  
Author: Scuteri, Angelo
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Scuteri, A. (n.d.). Plos One : Association of Chronic Kidney Disease and Peripheral Artery Disease with Inappropriate Left Ventricular Mass, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Inappropriate left ventricular mass index (LVM) may develop as a response to particular hemodynamic and metabolic alterations. Inappropriate LVM and peripheral artery disease (PAD) characterized by abnormally low or high ankle-brachial index (ABI) are common in chronic kidney disease (CKD) patients, in whom there may be a close and cause-effect relationship. The aim of this study is to assess whether CKD and abnormal ABI has an independent and additive association with inappropriate LVM. A total of 1110 patients were included in the study. Inappropriate LVM was defined as observed LVM more than 28% of the predicted value. The ABI was measured using an ABI-form device. PAD was defined as ABI ,0.9 or .1.3 in either leg. Multivariate analysis showed that patients with estimated glomerular filtration rate (eGFR) ,45 ml/ min/1.73 m2 (odds ratio [OR], 1.644: P = 0.011) and PAD (OR, 2.082: P = 0.002) were independently associated with inappropriate LVM. The interaction between eGFR ,45 ml/min/1.73 m2 and PAD on inappropriate LVM was statistically significant (P = 0.044). Besides, eGFR,45 ml/min/1.73 m2 (change in observed/predicted LVM, 19.949: P,0.001) and PAD (change in observed/predicted LVM, 11.818: P = 0.003) were also significantly associated with observed/predicted LVM. Our findings show that eGFR ,45 ml/min/1.73 m2 and PAD are independently and additively associated with inappropriate LVM and observed/predicted LVM. Assessments of eGFR and ABI may be useful in identifying patients with inappropriate LVM.

 

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