World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-specific Apoptosis ; Possible Role for Inhibition of Deubiquitinase Activity, Volume 7

By Galardy, Paul, J.

Click here to view

Book Id: WPLBN0003934369
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-specific Apoptosis ; Possible Role for Inhibition of Deubiquitinase Activity, Volume 7  
Author: Galardy, Paul, J.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Galardy, P. J. (n.d.). Plos One : Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-specific Apoptosis ; Possible Role for Inhibition of Deubiquitinase Activity, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Inhibition of the ubiquitin-proteasome system (UPS) of protein degradation is a valid anti-cancer strategy and has led to the approval of bortezomib for the treatment of multiple myeloma. However, the alternative approach of enhancing the degradation of oncoproteins that are frequently overexpressed in cancers is less developed. Betulinic acid (BA) is a plantderived small molecule that can increase apoptosis specifically in cancer but not in normal cells, making it an attractive anticancer agent. Our results in prostate cancer suggested that BA inhibited multiple deubiquitinases (DUBs), which resulted in the accumulation of poly-ubiquitinated proteins, decreased levels of oncoproteins, and increased apoptotic cell death. In normal fibroblasts, however, BA did not inhibit DUB activity nor increased total poly-ubiquitinated proteins, which was associated with a lack of effect on cell death. In the TRAMP transgenic mouse model of prostate cancer, treatment with BA (10 mg/kg) inhibited primary tumors, increased apoptosis, decreased angiogenesis and proliferation, and lowered androgen receptor and cyclin D1 protein. BA treatment also inhibited DUB activity and increased ubiquitinated proteins in TRAMP prostate cancer but had no effect on apoptosis or ubiquitination in normal mouse tissues. Overall, our data suggests that BA-mediated inhibition of DUBs and induction of apoptotic cell death specifically in prostate cancer but not in normal cells and tissues may provide an effective non-toxic and clinically selective agent for chemotherapy.

 

Click To View

Additional Books


  • Plos One : Invasion Dynamics of a Fish-f... (by )
  • Plos One : Alpha-tomatine Attenuation of... (by )
  • Plos One : T Cell Intrinsic Nod2 is Disp... (by )
  • Plos One : Mechanistic Comparison Betwee... (by )
  • Plos One : the Influence of Shyness on t... (by )
  • Plos One : a Functional Variant in the M... (by )
  • Plos One : Oral Probiotic Microcapsule F... (by )
  • Plos One : Diagnostic Performance of a R... (by )
  • Plos One : a Mode-of-action Approach for... (by )
  • Plos One : the Prevalence and Phenotype ... (by )
  • Plos One : Experimental Identification o... (by )
  • Plos One : Bpr0L075, 6-methoxy-3-39,49,5... Volume 7 (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.