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Plos One : Biomarkers of Plasmodium Falciparum Infection During Pregnancy in Women Living in Northeastern Tanzania, Volume 7

By Craig, Alister G.

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Book Id: WPLBN0003934452
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Biomarkers of Plasmodium Falciparum Infection During Pregnancy in Women Living in Northeastern Tanzania, Volume 7  
Author: Craig, Alister G.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Craig, A. G. (n.d.). Plos One : Biomarkers of Plasmodium Falciparum Infection During Pregnancy in Women Living in Northeastern Tanzania, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : In pregnant women, Plasmodium falciparum infections are an important cause of maternal morbidity as well as fetal and neonatal mortality. Erythrocytes infected by these malaria-causing parasites accumulate through adhesive interactions in placental intervillous spaces, thus evading detection in peripheral blood smears. Sequestered infected erythrocytes induce inflammation, offering the possibility of detecting inflammatory mediators in peripheral blood that could act as biomarkers of placental infection. In a longitudinal, prospective study in Tanzania, we quantified a range of different cytokines, chemokines and angiogenic factors in peripheral plasma samples, taken on multiple sequential occasions during pregnancy up to and including delivery, from P. falciparum-infected women and matched uninfected controls. The results show that during healthy, uninfected pregnancies the levels of most of the panel of molecules we measured were largely unchanged except at delivery. In women with P. falciparum, however, both comparative and longitudinal assessments consistently showed that the levels of IL-10 and IP-10 increased significantly whilst that of RANTES decreased significantly, regardless of gestational age at the time the infection was detected. ROC curve analysis indicated that a combination of increased IL-10 and IP-10 levels and decreased RANTES levels might be predictive of P. falciparum infections. In conclusion, our data suggest that host biomarkers in peripheral blood may represent useful diagnostic markers of P. falciparum infection during pregnancy, but placental histology results would need to be included to verify these findings.

 

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