World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice, Volume 7

By Manzoni, Olivier, Jacques

Click here to view

Book Id: WPLBN0003935072
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice, Volume 7  
Author: Manzoni, Olivier, Jacques
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Manzoni, O. J. (n.d.). Plos One : Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Ketamine is an anesthetic and a popular abusive drug. As an anesthetic, effects of ketamine on glutamate and GABA transmission have been well documented but little is known about its long-term effects on the dopamine system. In the present study, the effects of ketamine on dopamine were studied in vitro and in vivo. In pheochromocytoma (PC 12) cells and NGF differentiated-PC 12 cells, ketamine decreased the cell viability while increasing dopamine (DA) concentrations in a dose-related manner. However, ketamine did not affect the expression of genes involved in DA synthesis. In the long-term (3 months) ketamine treated mice, significant increases of DA contents were found in the midbrain. Increased DA concentrations were further supported by up-regulation of tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis. Activation of midbrain dopaminergic neurons could be related to ketamine modulated corticalsubcortical glutamate connections. Using western blotting, significant increases in BDNF protein levels were found in the midbrain, suggesting that perhaps BDNF pathways in the cortical-subcortical connections might contribute to the longterm ketamine induced TH upregulation. These data suggest that long-term ketamine abuse caused a delayed and persistent upregulation of subcortical DA systems, which may contribute to the altered mental status in ketamine abusers.

 

Click To View

Additional Books


  • Plos One : Topological Strata of Weighte... (by )
  • Plos One : Fine Particle, Ozone Exposure... (by )
  • Plos One : Vitamin D Deficiency in Medic... (by )
  • Plos One : Going Beyond the Millennium E... (by )
  • Plos One : Identification of Genes to Di... (by )
  • Plos One : Two Failures to Replicate Hig... (by )
  • Plos One : Search ; Spatially Explicit A... (by )
  • Plos One : a New Role of the Complement ... (by )
  • Plos One : Enriched Environment Prevents... (by )
  • Plos One : Moderate Heat Challenge Incre... (by )
  • Plos One : an Automated Hiv-1 Env-pseudo... (by )
  • Plos One : Undernutrition Affects Cell S... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.