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Plos One : Chronic Resveratrol Treatment Protects Pancreatic Islets Against Oxidative Stress in Db, Volume 7

By Maedler, Kathrin

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Book Id: WPLBN0003935079
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Chronic Resveratrol Treatment Protects Pancreatic Islets Against Oxidative Stress in Db, Volume 7  
Author: Maedler, Kathrin
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Maedler, K. (n.d.). Plos One : Chronic Resveratrol Treatment Protects Pancreatic Islets Against Oxidative Stress in Db, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Resveratrol (RSV) has anti-inflammatory and anti-oxidant actions which may contribute to its cardiovascular protective effects. We examined whether RSV has any beneficial effects on pancreatic islets in db/db mice, an animal model of type 2 diabetes. The db/db and db/dm mice (non-diabetic control) were treated with (db-RSV) or without RSV (db-control) (20 mg/ kg daily) for 12 weeks. After performing an intraperitoneal glucose tolerance test and insulin tolerance test, mice were sacrificed, the pancreas was weighed, pancreatic b-cell mass was quantified by point count method, and the amount of islet fibrosis was determined. 8-Hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, was determined in 24 h urine and pancreatic islets. RSV treatment significantly improved glucose tolerance at 2 hrs in db/db mice (P = 0.036), but not in db/ dm mice (P = 0.623). This was associated with a significant increase in both pancreas weight (P = 0.011) and b-cell mass (P = 0.016). Islet fibrosis was much less in RSV-treated mice (P = 0.048). RSV treatment also decreased urinary 8-OHdG levels (P = 0.03) and the percentage of islet nuclei that were positive for 8-OHdG immunostaining (P = 0.019). We conclude that RSV treatment improves glucose tolerance, attenuates b-cell loss, and reduces oxidative stress in type 2 diabetes. These findings suggest that RSV may have a therapeutic implication in the prevention and management of diabetes.

 

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