World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Circulating Angiopoietin-2 is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis, Volume 7

By Parikh, Samir, M.

Click here to view

Book Id: WPLBN0003935103
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Circulating Angiopoietin-2 is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis, Volume 7  
Author: Parikh, Samir, M.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Parikh, S. M. (n.d.). Plos One : Circulating Angiopoietin-2 is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood chronic kidney disease (CKD) even in the absence of diabetes and hypertension. We hypothesized that an alteration in angiopoietin-1 and -2, growth factors which regulate endothelial and vascular function could be involved. We report that the endothelial survival factor, angiopoietin-1 is low in children with pre-dialysis CKD whereas the pro-inflammatory angiopoietin-2 is elevated in children on dialysis. In dialysis patients, angiopoietin-2 positively correlated with time on dialysis, systolic blood pressure, and carotid artery intima media thickness. Elevated angiopoietin-2 levels in dialysis versus pre-dialysis CKD patients were also associated with an anti-angiogenic (high soluble VEGFR-1 and low VEGF-A) and pro-inflammatory (high urate, E-selectin, P-selectin and VCAM-1) milieu. Ang-2 was immunodetected in arterial biopsy samples whilst the expression of VEGF-A was significantly downregulated in dialysis patients. Serum urate correlated with angiopoietin-2 levels in dialysis patients and addition of uric acid was able to induce rapid release of angiopoietin-2 from cultured endothelial cells. Thus, angiopoietin-2 is a marker for cardiovascular disease in children on chronic dialysis and may act as an anti-angiogenic and pro-inflammatory effector in this context. The possibility that the release of angiopoietin-2 from endothelia is mediated by urate should be explored further.

 

Click To View

Additional Books


  • Plos One : Investigation of Hepatitis B ... (by )
  • Plos One : Global Microrna Profiling of ... (by )
  • Plos One : the Cranial Osteology and Fee... (by )
  • Plos One : Age-specific Gene Expression ... (by )
  • Plos One : Variable Strength of Forest S... (by )
  • Plos One : Osthole Attenuates Hepatic In... (by )
  • Plos One : Therapeutic Potential of Mese... (by )
  • Plos One : Gene Therapy Model of X-linke... (by )
  • Plos One : Nondestructive Intervention t... (by )
  • Plos One : Rapid and Sensitive Microrna ... (by )
  • Plos One : an Obligate Role of Oxytocin ... (by )
  • Plos One : Temporal Ordering of Cancer M... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.