World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins, Volume 7

By Dunaevsky, Anna

Click here to view

Book Id: WPLBN0003935348
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins, Volume 7  
Author: Dunaevsky, Anna
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Dunaevsky, A. (n.d.). Plos One : Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain. The postsynaptic density is a highly complex set of proteins organized into molecular networks that play a central role in behavior and disease. We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461. A large compositional overlap was observed: more than 70% of human postsynaptic density proteins were also observed in the mouse postsynaptic density. Quantitative analysis of postsynaptic density components in both species indicates a broadly similar profile of abundance but also shows that there is higher abundance variation between species than within species. Well known components of this synaptic structure are generally more abundant in the mouse postsynaptic density. Significant inter-species abundance differences exist in some families of key postsynaptic density proteins including glutamatergic neurotransmitter receptors and adaptor proteins. Furthermore, we have identified a closely interacting set of molecules enriched in the human postsynaptic density that could be involved in dendrite and spine structural plasticity. Understanding synapse proteome diversity within and between species will be important to further our understanding of brain complexity and disease

 

Click To View

Additional Books


  • Plos One : a Zo-1, Volume 8 (by )
  • Plos One : Auditory Cortical and Hippoca... (by )
  • Plos One : Patients with Severe Radiogra... (by )
  • Plos One : Revealing the Hyperdiverse Mi... (by )
  • Plos One : Prominin 1, Volume 8 (by )
  • Plos One : Assessment of the Association... (by )
  • Plos One : Illicit Drug Use is a Signifi... (by )
  • Plos One : Estimation of Hiv Incidence i... (by )
  • Plos One : Rab6A, Volume 8 (by )
  • Plos One : Feasibility and Safety of Cer... (by )
  • Plos One : Mitochondrial Toxicity Studie... (by )
  • Plos One : Comparison of Psychological S... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.