World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as Ccr5 Antagonists, Volume 7

By Wainberg, Mark

Click here to view

Book Id: WPLBN0003935976
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as Ccr5 Antagonists, Volume 7  
Author: Wainberg, Mark
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Wainberg, M. (n.d.). Plos One : Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as Ccr5 Antagonists, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : By using a fragment-assembly strategy and bioisosteric-replacement principle, a series of novel piperazine derivatives were designed, synthesized, and evaluated for their cellular target-effector fusion activities and in vitro antiviral activities against HIV-1. Preliminary structure-activity relationships (SARs) of target compounds were concluded in this study, and five compounds were found to exhibited medium to potent CCR5 fusion activities with IC50 values in low micromolar level. Among evaluated compounds, 23 h was found to be a CCR5 antagonist with an IC50 value of 6.29 mM and an anti-HIV-1 inhibitor with an IC50 value of 0.44 mM.

 

Click To View

Additional Books


  • Plos One : Random Effects Models and Mul... (by )
  • Plos One : Splicefinder – a Fast and Eas... (by )
  • Plos One : a Framework for Assessing Glo... (by )
  • Plos One : Ethnic Differences in Disabil... (by )
  • Plos One : L-carnosine Affects the Growt... (by )
  • Plos One : Mortality Trends in Women and... (by )
  • Plos One : Neural Sensitivity to Odorant... (by )
  • Plos One : Complete Genome Analysis of t... (by )
  • Plos One : Experimental Adaptation of Wi... (by )
  • Plos One : Gene Expression Profile of Pe... (by )
  • Plos One : Uniparental Markers of Contem... (by )
  • Plos One : Health-related Quality of Lif... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.