World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Effect of Ethanol on Differential Protein Production and Expression of Potential Virulence Functions in the Opportunistic Pathogen Acinetobacter Baumannii, Volume 7

By Kaufmann, Gunnar, F.

Click here to view

Book Id: WPLBN0003936730
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Effect of Ethanol on Differential Protein Production and Expression of Potential Virulence Functions in the Opportunistic Pathogen Acinetobacter Baumannii, Volume 7  
Author: Kaufmann, Gunnar, F.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Kaufmann, G. F. (n.d.). Plos One : Effect of Ethanol on Differential Protein Production and Expression of Potential Virulence Functions in the Opportunistic Pathogen Acinetobacter Baumannii, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Acinetobacter baumannii persists in the medical environment and causes severe human nosocomial infections. Previous studies showed that low-level ethanol exposure increases the virulence of A. baumannii ATCC 17978. To better understand the mechanisms involved in this response, 2-D gel electrophoresis combined with mass spectrometry was used to investigate differential protein production in bacteria cultured in the presence or absence of ethanol. This approach showed that the presence of ethanol significantly induces and represses the production of 22 and 12 proteins, respectively. Although over 25% of the ethanol-induced proteins were stress-response related, the overall bacterial viability was uncompromised when cultured under these conditions. Production of proteins involved in lipid and carbohydrate anabolism was increased in the presence of ethanol, a response that correlates with increased carbohydrate biofilm content, enhanced biofilm formation on abiotic surfaces and decrease bacterial motility on semi-solid surfaces. The presence of ethanol also induced the acidification of bacterial cultures and the production of indole-3-acetic acid (IAA), a ubiquitous plant hormone that signals bacterial stress-tolerance and promotes plant-bacteria interactions. These responses could be responsible for the significantly enhanced virulence of A. baumannii ATCC 17978 cells cultured in the presence of ethanol when tested with the Galleria mellonella experimental infection model. Taken together, these observations provide new insights into the effect of ethanol in bacterial virulence. This alcohol predisposes the human host to infections by A. baumannii and could favor the survival and adaptation of this pathogen to medical settings and adverse host environments.

 

Click To View

Additional Books


  • Plos One : Expression of Yeast Ndi1 Resc... (by )
  • Plos One : a Compensatory Mutation Provi... (by )
  • Plos One : Proteomic Changes Between Mal... (by )
  • Plos One : Estimation of Wheat Agronomic... (by )
  • Plos One : Giant Robber Crabs Monitored ... (by )
  • Plos One : Rehmannia Glutinosa Extract A... (by )
  • Plos One : Mobile Phones in a Traffic Fl... (by )
  • Plos One : Characterisation of the Trans... (by )
  • Plos One : 9-phenanthrol, a Trpm4 Inhibi... (by )
  • Plos One : Factors Predicting Reversion ... (by )
  • Plos One : Fracture in Asian Women with ... (by )
  • Plos One : the Rice R2R3-myb Transcripti... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.