World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Influence of Structural Symmetry on Protein Dynamics, Volume 7

By Fraternali, Franca

Click here to view

Book Id: WPLBN0003939525
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Influence of Structural Symmetry on Protein Dynamics, Volume 7  
Author: Fraternali, Franca
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


APA MLA Chicago

Fraternali, F. (n.d.). Plos One : Influence of Structural Symmetry on Protein Dynamics, Volume 7. Retrieved from

Description : Structural symmetry in homooligomeric proteins has intrigued many researchers over the past several decades. However, the implication of protein symmetry is still not well understood. In this study, we performed molecular dynamics (MD) simulations of two forms of trp RNA binding attenuation protein (TRAP), the wild-type 11-mer and an engineered 12-mer, having two different levels of circular symmetry. The results of the simulations showed that the inter-subunit fluctuations in the 11-mer TRAP were significantly smaller than the fluctuations in the 12-mer TRAP while the internal fluctuations were larger in the 11-mer than in the 12-mer. These differences in thermal fluctuations were interpreted by normal mode analysis and group theory. For the 12-mer TRAP, the wave nodes of the normal modes existed at the flexible interface between the subunits, while the 11-mer TRAP had its nodes within the subunits. The principal components derived from the MD simulations showed similar mode structures. These results demonstrated that the structural symmetry was an important determinant of protein dynamics in circularly symmetric homooligomeric proteins.


Click To View

Additional Books

  • Plos One : Lmna Knock-down Affects Diffe... (by )
  • Plos One : Identifying the World’s Most ... (by )
  • Plos One : the Effects of Topographical ... (by )
  • Plos One : Slaf-seq ; an Efficient Metho... (by )
  • Plos One : Yes, You Can a Speaker’s Pote... (by )
  • Plos One : Knowledge, Attitude, Practice... (by )
  • Plos One : Genetic Variants and Increase... (by )
  • Plos One : Enhanced Osteogenesis of Adip... (by )
  • Plos One : the Effect of Polychlorinated... (by )
  • Plos One : Anion-sensitive Fluorophore I... (by )
  • Plos One : Use of Pb-cre4 Mice for Mosai... (by )
  • Plos One : a Saccharomyces Cerevisiaeass... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.