World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Interleukin-19 Mediates Tissue Damage in Murine Ischemic Acute Kidney Injury, Volume 7

By Long, David

Click here to view

Book Id: WPLBN0003939736
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Interleukin-19 Mediates Tissue Damage in Murine Ischemic Acute Kidney Injury, Volume 7  
Author: Long, David
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Long, D. (n.d.). Plos One : Interleukin-19 Mediates Tissue Damage in Murine Ischemic Acute Kidney Injury, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : Inflammation and renal tubular injury are major features of acute kidney injury (AKI). Many cytokines and chemokines are released from injured tubular cells and acts as proinflammatory mediators. However, the role of IL-19 in the pathogenesis of AKI is not defined yet. In bilateral renal ischemia/reperfusion injury (IRI)-induced and HgCl2-induced AKI animal models, realtime quantitative (RTQ)-PCR showed that the kidneys, livers, and lungs of AKI mice expressed significantly higher IL-19 and its receptors than did sham control mice. Immunohistochemical staining showed that IL-19 and its receptors were strongly stained in the kidney, liver, and lung tissue of AKI mice. In vitro, IL-19 upregulated MCP-1, TGF-b1, and IL-19, and induced mitochondria-dependent apoptosis in murine renal tubular epithelial M-1 cells. IL-19 upregulated TNF-a and IL-10 in cultured HepG2 cells, and it increased IL-1b and TNF-a expression in cultured A549 cells. In vivo, after renal IRI or a nephrotoxic dose of HgCl2 treatment, IL-20R1-deficient mice (the deficiency blocks IL-19 signaling) showed lower levels of blood urea nitrogen (BUN) in serum and less tubular damage than did wild-type mice. Therefore, we conclude that IL-19 mediates kidney, liver, and lung tissue damage in murine AKI and that blocking IL-19 signaling may provide a potent therapeutic strategy for treating AKI.

 

Click To View

Additional Books


  • Plos One : Genomic and Functional Analys... (by )
  • Plos One : Bidirectional Scaling of Astr... (by )
  • Plos One : Murine Bone Marrow Lin2Sca-1+... (by )
  • Plos One : Understanding Long-term Varia... (by )
  • Plos One : Predicting Ad Conversion ; Co... (by )
  • Plos One : Evaluation of the Ins-1 832, ... (by )
  • Plos One : Dietary Effects on Cuticular ... (by )
  • Plos One : Aflatoxin B1 Up-regulates Ins... (by )
  • Plos One : Vitellogenins Are New High Mo... (by )
  • Plos One : Increased Circulating Th17 Ce... (by )
  • Plos One : Molecular Codes in Biological... (by )
  • Plos One : the Prothrombotic Phenotypes ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.