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Plos One : Investigating the Genetic Basis of Theory of Mind Tom ; the Role of Catechol- O-methyltransferase Comt Gene Polymorphisms, Volume 7

By Yoshikawa, Takeo

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Book Id: WPLBN0003939819
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Investigating the Genetic Basis of Theory of Mind Tom ; the Role of Catechol- O-methyltransferase Comt Gene Polymorphisms, Volume 7  
Author: Yoshikawa, Takeo
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Yoshikawa, T. (n.d.). Plos One : Investigating the Genetic Basis of Theory of Mind Tom ; the Role of Catechol- O-methyltransferase Comt Gene Polymorphisms, Volume 7. Retrieved from http://netlibrary.net/


Description
Description : The ability to deduce other persons’ mental states and emotions which has been termed ‘theory of mind (ToM)’ is highly heritable. First molecular genetic studies focused on some dopamine-related genes, while the genetic basis underlying different components of ToM (affective ToM and cognitive ToM) remain unknown. The current study tested 7 candidate polymorphisms (rs4680, rs4633, rs2020917, rs2239393, rs737865, rs174699 and rs59938883) on the catechol-Omethyltransferase (COMT) gene. We investigated how these polymorphisms relate to different components of ToM. 101 adults participated in our study: all were genetically unrelated, non-clinical and healthy Chinese subjects. Different ToM tasks were applied to detect their theory of mind ability. The results showed that the COMT gene rs2020917 and rs737865 SNPs were associated with cognitive ToM performance, while the COMT gene rs5993883 SNP was related to affective ToM, in which a significant gender-genotype interaction was found (p = 0.039). Our results highlighted the contribution of DArelated COMT gene on ToM performance. Moreover, we found out that the different SNP at the same gene relates to the discriminative aspect of ToM. Our research provides some preliminary evidence to the genetic basis of theory of mind which still awaits further studies.

 

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