World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Brief Bursts Self-inhibit and Correlate the Pyramidal Network, Volume 8

By Bacci, Alberto

Click here to view

Book Id: WPLBN0003940787
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Brief Bursts Self-inhibit and Correlate the Pyramidal Network, Volume 8  
Author: Bacci, Alberto
Volume: Volume 8
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Bacci, A. (n.d.). Plos Biology : Brief Bursts Self-inhibit and Correlate the Pyramidal Network, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect with pyramidal cells (PCs). One prominent pathway is the frequencydependent disynaptic inhibition (FDDI) formed between layer 5 PCs and mediated by Martinotti cells (MCs). Here, we show that simultaneous short bursts in four PCs are sufficient to exert FDDI in all neighboring PCs within the dimensions of a cortical column. This powerful inhibition is mediated by few interneurons, leading to strongly correlated membrane fluctuations and synchronous spiking between PCs simultaneously receiving FDDI. Somatic integration of such inhibition is independent and electrically isolated from monosynaptic excitation formed between the same PCs. FDDI is strongly shaped by I(h) in PC dendrites, which determines the effective integration time window for inhibitory and excitatory inputs. We propose a key disynaptic mechanism by which brief bursts generated by a few PCs can synchronize the activity in the pyramidal network.

 

Click To View

Additional Books


  • Plos Biology : Three-dimensional Maps of... (by )
  • Plos Biology : Reconstructing Speech fro... (by )
  • Plos Biology : a Role for Myosin VI in t... (by )
  • Plos Biology : Molecular Remodeling of T... (by )
  • Plos Biology : Cell Division in Apicompl... (by )
  • Plos Biology : Structural Basis of Respo... (by )
  • Plos Biology : a Genetic and Functional ... (by )
  • Plos Biology : Biochemical Characterizat... (by )
  • Plos Biology : Open Access Increases Cit... (by )
  • Plos Biology : Functional Modulation of ... (by )
  • Plos Biology : Bipartisan Bill for Publi... (by )
  • Plos Biology : Auditory Cortex Tracks Bo... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.