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Plos Biology : Cholinergic Activation of M2 Receptors Leads to Context- Dependent Modulation of Feedforward Inhibition in the Visual Thalamus, Volume 8

By Bacci, Alberto

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Book Id: WPLBN0003940796
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Cholinergic Activation of M2 Receptors Leads to Context- Dependent Modulation of Feedforward Inhibition in the Visual Thalamus, Volume 8  
Author: Bacci, Alberto
Volume: Volume 8
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Bacci, A. (n.d.). Plos Biology : Cholinergic Activation of M2 Receptors Leads to Context- Dependent Modulation of Feedforward Inhibition in the Visual Thalamus, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : In many brain regions, inhibition is mediated by numerous classes of specialized interneurons, but within the rodent dorsal lateral geniculate nucleus (dLGN), a single class of interneuron is present. dLGN interneurons inhibit thalamocortical (TC) neurons and regulate the activity of TC neurons evoked by retinal ganglion cells (RGCs), thereby controlling the visually evoked signals reaching the cortex. It is not known whether neuromodulation can regulate interneuron firing mode and the resulting inhibition. Here, we examine this in brain slices. We find that cholinergic modulation regulates the output mode of these interneurons and controls the resulting inhibition in a manner that is dependent on the level of afferent activity. When few RGCs are activated, acetylcholine suppresses synaptically evoked interneuron spiking, and strongly reduces disynaptic inhibition. In contrast, when many RGCs are coincidently activated, single stimuli promote the generation of a calcium spike, and stimulation with a brief train evokes prolonged plateau potentials lasting for many seconds that in turn lead to sustained inhibition. These findings indicate that cholinergic modulation regulates feedforward inhibition in a contextdependent manner.

 

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