World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Polarized Secretion of Drosophila Egfr Ligand from Photoreceptor Neurons is Controlled by Er Localization of the Ligand-processing MacHinery, Volume 8

By Basler, Konrad

Click here to view

Book Id: WPLBN0003940934
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Polarized Secretion of Drosophila Egfr Ligand from Photoreceptor Neurons is Controlled by Er Localization of the Ligand-processing MacHinery, Volume 8  
Author: Basler, Konrad
Volume: Volume 8
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Basler, K. (n.d.). Plos Biology : Polarized Secretion of Drosophila Egfr Ligand from Photoreceptor Neurons is Controlled by Er Localization of the Ligand-processing MacHinery, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : The release of signaling molecules from neurons must be regulated, to accommodate their highly polarized structure. In the developing Drosophila visual system, photoreceptor neurons secrete the epidermal growth factor receptor ligand Spitz (Spi) from their cell bodies, as well as from their axonal termini. Here we show that subcellular localization of Rhomboid proteases, which process Spi, determines the site of Spi release from neurons. Endoplasmic reticulum (ER) localization of Rhomboid 3 is essential for its ability to promote Spi secretion from axons, but not from cell bodies. We demonstrate that the ER extends throughout photoreceptor axons, and show that this feature facilitates the trafficking of the Spi precursor, the ligand chaperone Star, and Rhomboid 3 to axonal termini. Following this trafficking step, secretion from the axons is regulated in a manner similar to secretion from cell bodies. These findings uncover a role for the ER in trafficking proteins from the neuronal cell body to axon terminus.

 

Click To View

Additional Books


  • Plos Biology : the Interscutularis Muscl... (by )
  • Plos Biology : B Cell Antigen Receptor S... (by )
  • Plos Biology : Hrs and Snx3 Functions in... (by )
  • Plos Biology : Dances as Windows Into In... (by )
  • Plos Biology : Tsetse Flies Rely on Symb... (by )
  • Plos Biology : Don’t Get Too Comfortable... (by )
  • Plos Biology : Inherent Dynamics of the ... (by )
  • Plos Biology : Pandemic Infl Uenza ; the... (by )
  • Plos Biology : a Voltage-gated H+ Channe... (by )
  • Plos Biology : Activation-induced Cytidi... (by )
  • Plos Biology : Drosophila Neurotrophins ... (by )
  • Plos Biology : Functional Anatomy of Pol... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.