World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : a Simulation Tool for Dynamic Contrast Enhanced Mri, Volume 8

By Louie, Angelique

Click here to view

Book Id: WPLBN0003943092
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : a Simulation Tool for Dynamic Contrast Enhanced Mri, Volume 8  
Author: Louie, Angelique
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Louie, A. (n.d.). Plos One : a Simulation Tool for Dynamic Contrast Enhanced Mri, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : The quantification of bolus-tracking MRI techniques remains challenging. The acquisition usually relies on one contrast and the analysis on a simplified model of the various phenomena that arise within a voxel, leading to inaccurate perfusion estimates. To evaluate how simplifications in the interstitial model impact perfusion estimates, we propose a numerical tool to simulate the MR signal provided by a dynamic contrast enhanced (DCE) MRI experiment. Our model encompasses the intrinsic R1 and R2 relaxations, the magnetic field perturbations induced by susceptibility interfaces (vessels and cells), the diffusion of the water protons, the blood flow, the permeability of the vessel wall to the the contrast agent (CA) and the constrained diffusion of the CA within the voxel. The blood compartment is modeled as a uniform compartment. The different blocks of the simulation are validated and compared to classical models. The impact of the CA diffusivity on the permeability and blood volume estimates is evaluated. Simulations demonstrate that the CA diffusivity slightly impacts the permeability estimates (v5% for classical blood flow and CA diffusion). The effect of long echo times is investigated. Simulations show that DCE-MRI performed with an echo time TE~5ms may already lead to significant underestimation of the blood volume (up to 30% lower for brain tumor permeability values). The potential and the versatility of the proposed implementation are evaluated by running the simulation with realistic vascular geometry obtained from two photons microscopy and with impermeable cells in the extravascular environment. In conclusion, the proposed simulation tool describes DCE-MRI experiments and may be used to evaluate and optimize acquisition and processing strategies.

 

Click To View

Additional Books


  • Plos One : Rare Genomic Structural Varia... (by )
  • Plos One : Advanced Glycation End Produc... (by )
  • Plos One : Chromosome Copy Number Variat... (by )
  • Plos One : E- and P-selectins Are Essent... (by )
  • Plos One : Dipotassium Glycyrrhizate Inh... (by )
  • Plos One : Autochthonous Mouse Melanoma ... (by )
  • Plos One : Antenatal Depression in Anura... (by )
  • Plos One : Automated Authorship Attribut... (by )
  • Plos One : Inhibition of Hiv-1 Infection... (by )
  • Plos One : Higher Perceived Stress but L... (by )
  • Plos One : Somatic Mutations of Pik3R1Pr... (by )
  • Plos One : Simulating Polar Bear Energet... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.