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Plos One : Attenuation of Kru¨ Ppel-like Factor 4 Facilitates Carcinogenesis by Inducing G1, Volume 8

By Müller, Rolf

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Book Id: WPLBN0003944360
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Attenuation of Kru¨ Ppel-like Factor 4 Facilitates Carcinogenesis by Inducing G1, Volume 8  
Author: Müller, Rolf
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Müller, R. (n.d.). Plos One : Attenuation of Kru¨ Ppel-like Factor 4 Facilitates Carcinogenesis by Inducing G1, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Krüppel-like factor 4 (KLF4) is a transcription factor with diverse functions in various cancer types: however, the function of KLF4 in clear cell renal cell carcinoma (ccRCC) carcinogenesis remains unknown. In this study, we initially examined KLF4 expression by using a cohort of surgically removed ccRCC specimens and cell lines. Results indicated that the transcription and translation of KLF4 were lower in ccRCC tissues than in patient-matched normal tissues. Furthermore, the KLF4 expression was significantly downregulated in the five ccRCC cell lines at protein and mRNA levels compared with that in normal renal proximal tubular epithelial cell lines (HKC). KLF4 downregulation was significantly correlated with tumor stage and tumor diameter. Promoter hypermethylation may contribute to its low expression. In addition, in vitro studies indicated that the KLF4 overexpression significantly inhibited proliferation in human ccRCC cell lines 786-O and ACHN. Moreover, the KLF4 overexpression arrested the cell cycle progress at the G1/S phase transition by upregulating p21WAF1/CIP1 expression and downregulating cyclin D1 expression, KLF4 knockdown in HKC cells did the opposite. In vivo studies confirmed the antiproliferative effect of KLF4. Our results suggested that KLF4 had an important function in suppressing the growth of ccRCC.

 

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