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Plos One : Cd271 Defines a Stem Cell-like Population in Hypopharyngeal Cancer, Volume 8

By Kalinichenko, Vladimir, V.

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Book Id: WPLBN0003944946
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Cd271 Defines a Stem Cell-like Population in Hypopharyngeal Cancer, Volume 8  
Author: Kalinichenko, Vladimir, V.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Publication Date:
Publisher: Plos


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Kalinichenko, V. V. (n.d.). Plos One : Cd271 Defines a Stem Cell-like Population in Hypopharyngeal Cancer, Volume 8. Retrieved from

Description : Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271+ population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271+ cells contained both CD271+ and CD2712 cells, indicating that the population could undergo differentiation. Immunohistological analyses of the tumors revealed that the CD271+ cells localized to a perivascular niche near CD34+ vasculature, to invasive fronts, and to the basal layer. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly upregulated in the CD271+ compared to the CD2712 cell population. Furthermore, using primary HPC specimens, we demonstrated that high CD271 expression was correlated with a poor prognosis for patients. Taken together, our findings indicate that CD271 is a novel marker for HPC stem-like cells and for HPC prognosis


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