World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Differential Requirement for Ccr4 in the Maintenance but Not Establishment of the Invariant Vc5+ Dendritic Epidermal T-cell Pool, Volume 8

By Alberola-ila, Jose

Click here to view

Book Id: WPLBN0003946745
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Differential Requirement for Ccr4 in the Maintenance but Not Establishment of the Invariant Vc5+ Dendritic Epidermal T-cell Pool, Volume 8  
Author: Alberola-ila, Jose
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Alberola-Ila, J. (n.d.). Plos One : Differential Requirement for Ccr4 in the Maintenance but Not Establishment of the Invariant Vc5+ Dendritic Epidermal T-cell Pool, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Thymocytes expressing the invariant Vc5 cdT-cell receptor represent progenitors of dendritic epidermal T-cells (DETC) that play an important immune surveillance role in the skin. In contrast to the bulk of abT-cell development, Vc5+ DETC progenitor development occurs exclusively in fetal thymus. Whilst abT-cell development is known to require chemokine receptor mediated migration through distinct thymus regions, culminating in medullary entry and thymic egress, the importance and control of intrathymic migration for DETC progenitors is unclear. We recently revealed a link between Vc5+ DETC progenitor development and medullary thymic epithelial cells expressing Aire, a known regulator of thymic chemokine expression, demonstrating that normal Vc5+ DETC progenitor development requires regulated intramedullary positioning. Here we investigate the role of chemokines and their receptors during intrathymic Vc5+ DETC progenitor development and establishment of the DETC pool in the skin. We report that thymic medullary accumulation of Vc5+ DETC progenitors is a G-protein coupled receptor dependent process. However, this process occurs independently of Aire’s influences on intrathymic chemokines, and in the absence of CCR4 and CCR7 expression by DETC progenitors. In contrast, analysis of epidermal cdT-cells at neonatal and adult stages in CCR42/2 mice reveals that reduced numbers of DETC in adult epidermis are not a consequence of diminished intrathymic embryonic development, nor deficiencies in initial epidermal seeding in the neonate. Collectively, our data reveal differences in the chemokine receptor requirements for intrathymic migration of ab and invariant cdT-cells, and highlight a differential role for CCR4 in the maintenance, but not initial seeding, of DETC in the epidermis.

 

Click To View

Additional Books


  • Plos One : Brain Changes in Long-term Ze... (by )
  • Plos One : Snp Discovery in European Anc... (by )
  • Plos One : the Formation Mechanism of De... (by )
  • Plos One : Preparing Offspring for a Dan... (by )
  • Plos One : Island Evolution and Systemat... (by )
  • Plos One : Electrocardiographic Changes ... (by )
  • Plos One : Relatively Recent Evolution o... (by )
  • Plos One : Gymnemic Acids Inhibit Hyphal... (by )
  • Plos One : a Clinically Integrated Post-... (by )
  • Plos One : Humans Strengthen Bottom-up E... (by )
  • Plos One : Structural Analysis of Peptid... (by )
  • Plos One : Lack of Association Between H... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.