World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Distinct Roles for Cxcr6+ and Cxcr62 Cd4+ T Cells in the Pathogenesis of Chronic Colitis, Volume 8

By Mizoguchi, Emiko

Click here to view

Book Id: WPLBN0003946911
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Distinct Roles for Cxcr6+ and Cxcr62 Cd4+ T Cells in the Pathogenesis of Chronic Colitis, Volume 8  
Author: Mizoguchi, Emiko
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Mizoguchi, E. (n.d.). Plos One : Distinct Roles for Cxcr6+ and Cxcr62 Cd4+ T Cells in the Pathogenesis of Chronic Colitis, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : CD4+ T cells play a central role in the development of inflammatory bowel disease (IBD) via high-level production of effector cytokines such as IFN-c and TNF-a. To better characterize the colitogenic CD4+ T cells, we examined their expression of CXCR6, a chemokine receptor that is expressed by T cells upon activation and is upregulated in several inflammatory diseases. We found that 80% of colonic lamina propria CD4+ T cells expressed CXCR6 in the CD45RBhigh T cell-transferred colitis model. CXCR6 expression was similarly upregulated in inflamed mucosa of patients with Crohn’s disease. Although surface marker analysis demonstrated that both CXCR6+ and CXCR62 CD4+ T-cell subsets consist of the cells with effector and effector-memory cells, the more cells in the CXCR6+ subset produced IFN-c and TNF-a compared to CXCR62 subset, and only the CXCR6+ subset produced IL-17A. Nevertheless, adoptive retransfer of lamina propria CXCR6+ T cells into Rag12/ 2 recipients failed to induce the disease due to limited expansion of the transferred cells. By contrast, retransfer of CXCR62 cells evoked colitis similar to that observed in CD4+CD45RBhigh T cell-transferred mice, and resulted in their conversion into CXCR6+ cells. Collectively, these observations suggest that the CXCR6+CD4+ T-cell subset consists of terminally differentiated effector cells that serve as the major source of effector cytokines in the inflamed tissue, whereas CXCR62CD4+ T-cell subset serves as a colitogenic memory compartment that retains the ability to proliferate and differentiate into CXCR6+CD4+ T cells.

 

Click To View

Additional Books


  • Plos One : Prevalence of Human Papilloma... (by )
  • Plos One : Rapid Evolution of the Sequen... (by )
  • Plos One : Life History Changes in Coral... (by )
  • Plos One : Differences in Aqueous Concen... (by )
  • Plos One : Time Course of Current of Inj... (by )
  • Plos One : Life Years Lost Associated wi... (by )
  • Plos One : Herv-e-mediated Modulation of... (by )
  • Plos One : Neuronal Apoptosis and Motor ... (by )
  • Plos One : the Effect of Orexin-a on Car... (by )
  • Plos One : Social Support, Socio-economi... (by )
  • Plos One : a Biophysical Model for Ident... (by )
  • Plos One : the Dynamic Range Paradox ; a... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.