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Plos One : Enhanced Immune Response and Protective Effects of Nano-chitosan-based Dna Vaccine Encoding T Cell Epitopes of Esat-6 and Fl Against Mycobacterium Tuberculosis Infection, Volume 8

By Doherty, T. Mark

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Book Id: WPLBN0003947758
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Enhanced Immune Response and Protective Effects of Nano-chitosan-based Dna Vaccine Encoding T Cell Epitopes of Esat-6 and Fl Against Mycobacterium Tuberculosis Infection, Volume 8  
Author: Doherty, T. Mark
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Doherty, T. M. (n.d.). Plos One : Enhanced Immune Response and Protective Effects of Nano-chitosan-based Dna Vaccine Encoding T Cell Epitopes of Esat-6 and Fl Against Mycobacterium Tuberculosis Infection, Volume 8. Retrieved from http://netlibrary.net/


Description
Description : Development of a novel and effective vaccine against Mycobacterium tuberculosis (M.tb) is a challenging for preventing TB infection. In this study, a novel nanoparticle-based recombinant DNA vaccine was developed, which contains Esat-6 three T cell epitopes (Esat-6/3e) and fms-like tyrosine kinase 3 ligand (FL) genes (termed Esat-6/3e-FL), and was enveloped with chitosan (CS) nanoparticles (nano-chitosan). The immunologic and protective efficacy of the nano-chitosan-based DNA vaccine (termed nano-Esat-6/3e-FL) was assessed in C57BL/6 mice after intramuscular prime vaccination with the plasmids DNA and nasal boost with the Esat-6/3e peptides. The results showed that the immunized mice remarkably elicited enhanced T cell responses and protection against M.tb H37Rv challenge. These findings indicate that the nano-chitosan can significantly elevate the immunologic and protective effects of the DNA vaccine, and the nano-Esat-6/3e-FL is a useful vaccine for preventing M.tb infection in mice.

 

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