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Plos One : Fully Bayesian Inference for Structural Mri ; Application to Segmentation and Statistical Analysis of T2-hypointensities, Volume 8

By Rapallo, Fabio

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Book Id: WPLBN0003948715
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Fully Bayesian Inference for Structural Mri ; Application to Segmentation and Statistical Analysis of T2-hypointensities, Volume 8  
Author: Rapallo, Fabio
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Rapallo, F. (n.d.). Plos One : Fully Bayesian Inference for Structural Mri ; Application to Segmentation and Statistical Analysis of T2-hypointensities, Volume 8. Retrieved from http://netlibrary.net/


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Description : Aiming at iron-related T2-hypointensity, which is related to normal aging and neurodegenerative processes, we here present two practicable approaches, based on Bayesian inference, for preprocessing and statistical analysis of a complex set of structural MRI data. In particular, Markov Chain Monte Carlo methods were used to simulate posterior distributions. First, we rendered a segmentation algorithm that uses outlier detection based on model checking techniques within a Bayesian mixture model. Second, we rendered an analytical tool comprising a Bayesian regression model with smoothness priors (in the form of Gaussian Markov random fields) mitigating the necessity to smooth data prior to statistical analysis. For validation, we used simulated data and MRI data of 27 healthy controls (age : 30+9: range, 20{58). We first observed robust segmentation of both simulated T2-hypointensities and gray-matter regions known to be T2-hypointense. Second, simulated data and images of segmented T2-hypointensity were analyzed. We found not only robust identification of simulated effects but also a biologically plausible age-related increase of T2-hypointensity primarily within the dentate nucleus but also within the globus pallidus, substantia nigra, and red nucleus. Our results indicate that fully Bayesian inference can successfully be applied for preprocessing and statistical analysis of structural MRI data.

 

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